Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition

@article{Archer2018ResistanceTP,
  title={Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition},
  author={N. Archer and Nicole Petersen and M. Clark and C. Buckee and L. Childs and M. Duraisingh},
  journal={Proceedings of the National Academy of Sciences},
  year={2018},
  volume={115},
  pages={7350 - 7355}
}
Significance Sickle cell trait has repeatedly been identified as a major human malaria resistance factor. Despite this, the exact mechanism of resistance is unclear. These studies demonstrate how the evolutionarily significant sickle hemoglobin affects Plasmodium falciparum infection success and leads to a better understanding of the molecular basis and pathogenesis of malaria infection. Sickle cell trait (AS) confers partial protection against lethal Plasmodium falciparum malaria. Multiple… Expand
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