Resistance to Nucleotide Excision Repair of Bulky Guanine Adducts Opposite Abasic Sites in DNA Duplexes and Relationships between Structure and Function

@inproceedings{Liu2015ResistanceTN,
  title={Resistance to Nucleotide Excision Repair of Bulky Guanine Adducts Opposite Abasic Sites in DNA Duplexes and Relationships between Structure and Function},
  author={Zhi Liu and Shuang Ding and Konstantin Y Kropachev and Jia Chuan Lei and Shantu Amin and Suse Broyde and Nicholas E. Geacintov and M. Ashley Spies},
  booktitle={PloS one},
  year={2015}
}
The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all base pairs are complementary. Here we show that the nucleotide excision repair activity in human cell… CONTINUE READING