Resistance to High-Fat Diet–Induced Obesity but Exacerbated Insulin Resistance in Mice Overexpressing Preadipocyte Factor-1 (Pref-1)

@article{Villena2008ResistanceTH,
  title={Resistance to High-Fat Diet–Induced Obesity but Exacerbated Insulin Resistance in Mice Overexpressing Preadipocyte Factor-1 (Pref-1)},
  author={Josep A. Villena and Cheol Soo Choi and Y X Rachel Wang and Sheene Kim and Yu-Jin Hwang and Young-Bum Kim and Gary W. Cline and Gerald I Shulman and Hei Sook Sul},
  journal={Diabetes},
  year={2008},
  volume={57},
  pages={3258 - 3266}
}
OBJECTIVE White adipose tissue is a critical regulator of whole-body glucose metabolism. Preadipocyte factor-1 (Pref-1) is a secreted protein that inhibits adipocyte differentiation, both in vitro and in vivo. In this study, we have investigated the effects of Pref-1 overexpression on whole-body glucose homeostasis and its contribution to the development of insulin resistance. RESEARCH DESIGN AND METHODS To gain insight into the role of Pref-1 on the onset of insulin resistance and type 2… CONTINUE READING