Resistance to HSV-1 Infection in the Epithelium Resides with the Novel Innate Sensor, IFI-16

Abstract

Toll-like receptors (TLRs) are innate sentinels required for clearance of bacterial and fungal infections of the cornea, but their role in viral immunity is currently unknown. We report that TLR signaling is expendable in herpes simplex virus (HSV)-1 containment as depicted by plaque assays of knockout mice (MyD88−/−, Trif−/− and MyD88−/− Trif−/− double… (More)
DOI: 10.1038/mi.2011.63

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