Resistance to HSP90 inhibition involving loss of MCL1 addiction

@inproceedings{Busacca2016ResistanceTH,
  title={Resistance to HSP90 inhibition involving loss of MCL1 addiction},
  author={Sara Busacca and Ethan William Law and Ian R. Powley and David A. Proia and M. Sequeira and John Le Quesne and Astero Klabatsa and J. M. Edwards and Kari Matchett and Jin Lian Luo and James H. Pringle and M El-Tanani and Marion Macfarlane and D. A. Fennell},
  booktitle={Oncogene},
  year={2016}
}
Inhibition of the chaperone heat-shock protein 90 (HSP90) induces apoptosis, and it is a promising anti-cancer strategy. The mechanisms underpinning apoptosis activation following HSP90 inhibition and how they are modified during acquired drug resistance are unknown. We show for the first time that, to induce apoptosis, HSP90 inhibition requires the cooperation of multi BH3-only proteins (BID, BIK, PUMA) and the reciprocal suppression of the pro-survival BCL-2 family member MCL1, which occurs… CONTINUE READING
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