Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

@article{Samson1996ResistanceTH,
  title={Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene},
  author={Michel Samson and Frédérick Libert and Benjamin J. Doranz and Joseph B. Rucker and Corinne Liesnard and Claire Mich{\`e}le Farber and Sentob Saragosti and Claudine Lapoum{\'e}roulie and Jacqueline Cognaux and C Forceille and Ga{\"e}tan Muyldermans and Chris Verhofstede and Guy Burtonboy and Michel Georges and Tsuneo Imai and Shalini Rana and Yanjie Yi and Robert J Smyth and Ronald G. Collman and Robert W. Doms and Gilbert Vassart and Marc Parmentier},
  journal={Nature},
  year={1996},
  volume={382},
  pages={722-725}
}
HIV-1 and related viruses require co-receptors, in addition to CD4, to infect target cells. The chemokine receptor CCR-5 (ref. 1) was recently demonstrated to be a co-receptor for macrophage-tropic (M-tropic) HIV-1 strains2–6, and the orphan7 receptor LESTR (also called fusin) allows infection by strains adapted for growth in transformed T-cell lines (T-tropic strains). Here we show that a mutant allele of CCR-5 is present at a high frequency in caucasian populations (allele frequency, 0.092… 

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TLDR
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TLDR
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TLDR
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