Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

  title={Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene},
  author={Michel Samson and Frédérick Libert and Benjamin J. Doranz and Joseph B. Rucker and Corinne Liesnard and Claire Mich{\`e}le Farber and Sentob Saragosti and Claudine Lapoum{\'e}roulie and Jacqueline Cognaux and C Forceille and Ga{\"e}tan Muyldermans and Chris Verhofstede and Guy Burtonboy and Michel Georges and Tsuneo Imai and Shalini Rana and Yanjie Yi and Robert J Smyth and Ronald G. Collman and Robert W. Doms and Gilbert Vassart and Marc Parmentier},
HIV-1 and related viruses require co-receptors, in addition to CD4, to infect target cells. The chemokine receptor CCR-5 (ref. 1) was recently demonstrated to be a co-receptor for macrophage-tropic (M-tropic) HIV-1 strains2–6, and the orphan7 receptor LESTR (also called fusin) allows infection by strains adapted for growth in transformed T-cell lines (T-tropic strains). Here we show that a mutant allele of CCR-5 is present at a high frequency in caucasian populations (allele frequency, 0.092… 

Downregulation of the CCR5 beta-chemokine receptor and inhibition of HIV-1 infection by stable VA1-ribozyme chimeric transcripts.

A hammerhead ribozyme (RZ) is designed that specifically targets the CCR5 mRNA and lacks complementarity to other members of the chemokine receptor gene family, and should prove useful in both studies of C CR5 receptor function and therapeutic intervention of monocytotropic HIV-1 infection.

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Antigen-driven C–C Chemokine-mediated HIV-1 Suppression by CD4+ T Cells from Exposed Uninfected Individuals Expressing the Wild-type CCR-5 Allele

Evidence of an oligoclonal T cell response mediated by helper T cells specific for a conserved region of the HIV-1 envelope is found, which may be part of a protective immune response that could be potentially exploited for vaccine development.

Determination of the Existence and Distribution of HIV-I Chemokine Co-Receptor 5 Polymorphism in a Sampled Population from Kenya

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CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

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CCR 5 genotype and plasma ß-chemokine concentration of Brazilian HIV-infected individuals

It is suggested that the CCR5 allele and ß-chemokine production may affect the immunopathogenesis of HIV-1.



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HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

The β-chemokines MIP-1α, MIP-1β and RANTES inhibit infection of CD4+ cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell–cell

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A sensitive reporter cell line for HIV-1 tat activity, HIV-1 inhibitors, and T cell activation effects.

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