Resistance to HER2 inhibitors: is addition better than substitution? Rationale for the hypothetical concept of drug sedimentation.

@article{Campone2011ResistanceTH,
  title={Resistance to HER2 inhibitors: is addition better than substitution? Rationale for the hypothetical concept of drug sedimentation.},
  author={Mario Campone and Philippe P Juin and Fabrice Andre and Thomas Bachelot},
  journal={Critical reviews in oncology/hematology},
  year={2011},
  volume={78 3},
  pages={195-205}
}
Twenty years were passed between the discovery of oncogene HER2, the description of its implication in mammary carcinogenesis, and the development of specific targeted therapies. To date, trastuzumab and lapatinib are the two anti-HER2 targeted therapies commonly used, demonstrating therapeutic effects. Although their clinical efficacy seems to be exclusively related to the amplification of the HER2 gene or to the overexpression of the protein, these factors are not sufficient since tumors can… CONTINUE READING

From This Paper

Topics from this paper.