Resistance to Coccidioides immitis in mice after immunization with recombinant protein or a DNA vaccine of a proline-rich antigen.

@article{Abuodeh1999ResistanceTC,
  title={Resistance to Coccidioides immitis in mice after immunization with recombinant protein or a DNA vaccine of a proline-rich antigen.},
  author={Raed O. Abuodeh and Lisa F Shubitz and Edward L. Siegel and Stacey Snyder and Tao Peng and K. Orsborn and Elmer Brummer and David A Stevens and John N. Galgiani},
  journal={Infection and immunity},
  year={1999},
  volume={67 6},
  pages={2935-40}
}
Two inbred strains of mice (BALB/c and C57BL/6) were vaccinated with either recombinant expression protein of a Coccidioides immitis spherule-derived proline-rich antigen (rPRA) in monophosphoryl lipid A-oil emulsion adjuvant or a DNA vaccine based on the same antigen. Four weeks after vaccination, mice were infected intraperitoneally with arthroconidia. By 2 weeks, groups of mice receiving saline or plasmids with no PRA insert exhibited significant weight loss, and quantitative CFUs in the… CONTINUE READING

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