Resistance to Bombyx mori nucleopolyhedrovirus via overexpression of an endogenous antiviral gene in transgenic silkworms

@article{Jiang2012ResistanceTB,
  title={Resistance to Bombyx mori nucleopolyhedrovirus via overexpression of an endogenous antiviral gene in transgenic silkworms},
  author={Liang Jiang and Genhong Wang and Tingcai Cheng and Qiong Yang and Shengkai Jin and Gai Lu and Fuquan Wu and Yang Xiao and Hanfu Xu and Qingyou Xia},
  journal={Archives of Virology},
  year={2012},
  volume={157},
  pages={1323-1328}
}
Transgenic technology is a powerful tool for improving disease-resistant species. Bmlipase-1, purified from the midgut juice of Bombyx mori, showed strong antiviral activity against B. mori nucleopolyhedrovirus (BmNPV). In an attempt to create an antiviral silkworm strain for sericulture, a transgenic vector overexpressing the Bmlipase-1 gene was constructed under the control of a baculoviral immediate early-1 (IE1) promoter. Transgenic lines were generated via embryo microinjection. The mRNA… CONTINUE READING