Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10

Abstract

BACKGROUND Matrix metalloproteinases (MMPs) may have pro and antifibrotic roles within the lungs, due to its ability to modulate collagen turnover and immune mediators. MMP-8 is a collagenase that also cleaves a number of cytokines and chemokines. METHODOLOGY AND PRINCIPAL FINDINGS To evaluate its relevance in lung fibrosis, wildtype and Mmp8(-/-) mice… (More)
DOI: 10.1371/journal.pone.0013242

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