Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

@inproceedings{Baenke2016ResistanceTB,
  title={Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells},
  author={Franziska Baenke and Barbara Chaneton and Matthew Smith and Niels J. F. van den Broek and Kate Hogan and Haoran Tang and Amaya Vir{\'o}s and Matthew J. Martin and Laura C. A. Galbraith and Mar{\'i}a R. Girotti and Nathalie S Dhomen and Eyal Gottlieb and Richard Marais},
  booktitle={Molecular oncology},
  year={2016}
}
BRAF inhibitors can extend progression-free and overall survival in melanoma patients whose tumors harbor mutations in BRAF. However, the majority of patients eventually develop resistance to these drugs. Here we show that BRAF mutant melanoma cells that have developed acquired resistance to BRAF inhibitors display increased oxidative metabolism and… CONTINUE READING