Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor.

@article{Bunger2003ResistanceT2,
  title={Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor.},
  author={Maureen K. Bunger and Susan M. Moran and Edward Glover and Tami L. Thomae and Garet P Lahvis and Bernice C Lin and Christopher A. Bradfield},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 20},
  pages={17767-74}
}
The Ah receptor (AHR) mediates the metabolic adaptation to a number of planar aromatic chemicals. Essential steps in this adaptive mechanism include AHR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the Ah receptor nuclear translocator, and binding of this heterodimeric transcription factor to dioxin-responsive elements (DREs) upstream of promoters that regulate the expression of genes involved in xenobiotic metabolism. The AHR is also… CONTINUE READING

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