Resistance studies with daptomycin.


We studied the in vitro emergence of resistance to daptomycin using three methods: spontaneous resistance incidence, serial passage in the presence of increasing drug concentrations, and chemical mutagenesis. No spontaneously resistant mutants were obtained for any organism tested (<10(-10) for Staphylococcus aureus, <10(-9) for Staphylococcus epidermidis… (More)


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@article{Silverman2001ResistanceSW, title={Resistance studies with daptomycin.}, author={Jared A. Silverman and Noelynn Oliver and T. M. Andrew and T Li}, journal={Antimicrobial agents and chemotherapy}, year={2001}, volume={45 6}, pages={1799-802} }