Resistance of the ovary to blockade of aromatization with aminoglutethimide.

@article{Santen1980ResistanceOT,
  title={Resistance of the ovary to blockade of aromatization with aminoglutethimide.},
  author={Richard J. Santen and E. Samojlik and Samuel A. Wells},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1980},
  volume={51 3},
  pages={473-7}
}
Aminoglutethimide (AG) is a potent inhibitor of aromatization in placental microsomes and in peripheral tissues in postmenopausal women. Aromatase inhibitors have been used to block estrogen production and induce breast tumor regression in rodents. To inhibit ovarian estrogen production, we administered various doses of AG and its highly potent D-stereoisomer to premenopausal women with breast carcinoma. However, at no dose level did AG consistently lower estrone and estradiol concentrations in… CONTINUE READING

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