Resistance of the dopamine D2L receptor to desensitization accompanies the up-regulation of receptors on to the surface of Sf9 cells.

@article{Ng1997ResistanceOT,
  title={Resistance of the dopamine D2L receptor to desensitization accompanies the up-regulation of receptors on to the surface of Sf9 cells.},
  author={Gordon Y K Ng and George Varghese and Hun Taeg Chung and Judy E Trogadis and Philip Seeman and Brian F O'dowd and Susan R. George},
  journal={Endocrinology},
  year={1997},
  volume={138 10},
  pages={4199-206}
}
Dopamine D2 receptor agonists are commonly used in the control of PRL-secreting adenomas, and the sensitivity of dopamine agonists during long term therapy is exquisite. However, the molecular mechanisms responsible for the maintenance of this cellular sensitivity to dopamine agonists remain poorly understood. In the present study, we examined the agonist-induced regulation of the human D2L receptor expressed to a specific activity of approximately 1 pmol receptor/mg protein in Sf9 insect cells… CONTINUE READING