Resistance of the Echinococcus granulosus cyst wall to complement activation: analysis of the role of InsP6 deposits.

@article{Irigon2008ResistanceOT,
  title={Resistance of the Echinococcus granulosus cyst wall to complement activation: analysis of the role of InsP6 deposits.},
  author={Florencia Irigo{\'i}n and Andreas Laich and Ana Mar{\'i}a Ferreira and Cecilia Fern{\'a}ndez and Robert B Sim and Alvaro Diaz},
  journal={Parasite immunology},
  year={2008},
  volume={30 6-7},
  pages={354-64}
}
The larva of the cestode Echinococcus granulosus (hydatid cyst) is protected by the acellular laminated layer (LL). The mechanisms that make this thick coat a poor activator of host complement are incompletely understood. The structure binds, through unknown motifs, the host regulator of the alternative complement pathway (ACP), factor H. A second potential mechanism of ACP regulation, the inhibition of factor B activation, was detected in assays employing purified components… CONTINUE READING