Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1.

@article{Furfaro2012ResistanceON,
  title={Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1.},
  author={Anna Lisa Furfaro and Jos{\'e} Ra{\'u}l Zumba Macay and Barbara Marengo and Mariapaola Nitti and Alessia Parodi and Daniela Fenoglio and Umberto Maria Marinari and Maria Adelaide Pronzato and Cinzia Domenicotti and Nicola Traverso},
  journal={Free radical biology & medicine},
  year={2012},
  volume={52 2},
  pages={488-96}
}
Cancer cell survival is known to be related to the ability to counteract oxidative stress, and glutathione (GSH) depletion has been proposed as a mechanism to sensitize cells to anticancer therapy. However, we observed that GI-ME-N cells, a neuroblastoma cell line without MYCN amplification, are able to survive even if GSH-depleted by l-buthionine-(S,R)-sulfoximine (BSO). Here, we show that in GI-ME-N cells, BSO activates Nrf2 and up-regulates heme oxygenase-1 (HO-1). Silencing of Nrf2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…