Resistance of naive mice to murine hepatitis virus strain 3 requires development of a Th1, but not a Th2, response, whereas pre-existing antibody partially protects against primary infection.

@article{Liu1998ResistanceON,
  title={Resistance of naive mice to murine hepatitis virus strain 3 requires development of a Th1, but not a Th2, response, whereas pre-existing antibody partially protects against primary infection.},
  author={Mingfeng Liu and Xiaoyang Wan and Melissa Pope and Tim Mosmann and Julian L. Leibowitz and Jin Wen Ding and Laisum S Fung and Ori D. Rotstein and Reginald M Gorczynski and Gary A. Levy},
  journal={Advances in experimental medicine and biology},
  year={1998},
  volume={440},
  pages={415-23}
}
Murine hepatitis virus strain 3 (MHV-3) produces a host-strain-dependent spectrum of disease. The development of liver necrosis has been shown to be related to production of a unique macrophage procoagulant activity (PCA), encoded by the gene fgl-2, in susceptible mice. These studies were designed to examine the influence of Th1/Th2 cells on resistance/susceptibility and production of macrophage procoagulant activity (PCA) in resistant (A/J) and susceptible (Balb/cJ) strains of mice following… CONTINUE READING

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