Resistance of human multidrug-resistant neoplastic cell lines to paclitaxel-induced-radiosensitization is reduced by the non-immunosuppressive cyclosporine analog SDZ PSC 833.

Abstract

The non-immunosuppressive cyclosporine analog SDZ PSC 833 abolished the resistance of human multidrug resistant (MDR-1, P-gp) human promyelocyte leukemia HL-60/VCR cells in vitro to paclitaxel-induced cell cycle- and viability alterations, as well as resistance to paclitaxel-induced radiosensitization. Furthermore, SDZ PSC 833 abolished also the resistance… (More)

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@article{Sedlk1998ResistanceOH, title={Resistance of human multidrug-resistant neoplastic cell lines to paclitaxel-induced-radiosensitization is reduced by the non-immunosuppressive cyclosporine analog SDZ PSC 833.}, author={Jan Sedl{\'a}k and Luba Hunakova and Martin Chorv{\'a}th and M Sul{\'i}kov{\'a} and Ladislav Novotn{\'y} and Elena Bolje{\vs}{\'i}kov{\'a} and Robert Zeillinger and Branko Chorvath}, journal={Anticancer research}, year={1998}, volume={18 4C}, pages={3099-105} }