Resistance of human hepatitis B virus to reverse transcriptase inhibitors: from genotypic to phenotypic testing.

@article{Durantel2005ResistanceOH,
  title={Resistance of human hepatitis B virus to reverse transcriptase inhibitors: from genotypic to phenotypic testing.},
  author={David Durantel and Marie-Noelle Brunelle and Edwige Gros and Sandra Carrou{\'e}e-Durantel and Christian Pichoud and St{\'e}phanie Villet and Christian Tr{\'e}po and Fabien Zoulim},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2005},
  volume={34 Suppl 1},
  pages={
          S34-43
        }
}
The treatment of HBV infected patients with analogues of nucleos(t)ides, including lamivudine and adefovir dipivoxil, has significantly increased the rate of anti-HBe seroconversion and therefore reduced the impact of chronic hepatitis B (CHB) on liver disease. Altogether, these antivirals have offered novel options for the treatment of patients who did not respond to previous therapy with interferon alpha, the only available treatment against CHB until 1998. However, therapies using analogues… CONTINUE READING
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