Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.

@article{Hardee2012ResistanceOG,
  title={Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.},
  author={Matthew E. Hardee and Ariel E. Marciscano and Christina M Medina-Ramirez and David Zagzag and A. Venkata Narayana and Scott M Lonning and Mary Helen Barcellos-Hoff},
  journal={Cancer research},
  year={2012},
  volume={72 16},
  pages={4119-29}
}
The poor prognosis of glioblastoma (GBM) routinely treated with ionizing radiation (IR) has been attributed to the relative radioresistance of glioma-initiating cells (GIC). Other studies indicate that although GIC are sensitive, the response is mediated by undefined factors in the microenvironment. GBM produce abundant transforming growth factor-β (TGF-β), a pleotropic cytokine that promotes effective DNA damage response. Consistent with this, radiation sensitivity, as measured by clonogenic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 83 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Inhibition of TGFb1 signaling attenuates ATM activity in response to genotoxic stress

  • J Kirshner, MF Jobling, MJ Pajares, SA Ravani, A Glick, M Lavin
  • Cancer Res
  • 2006
Highly Influential
4 Excerpts

Isoform specificity of redox-mediated TGF-b activation

  • JoblingMF, JD Mott, FinneganM, EricksonAC, SE Taylor, S Ledbetter
  • Radiat Res
  • 2006
Highly Influential
5 Excerpts

Cancer stem cells: targets and potential biomarkers for radiotherapy

  • KrauseM, A Yaromina, W Eicheler, U Koch, BaumannM
  • Clin Cancer Res 2011;17:7224–9
  • 2012
1 Excerpt

Similar Papers

Loading similar papers…