Resistance of cutaneous anaplastic large-cell lymphoma cells to apoptosis by death ligands is enhanced by CD30-mediated overexpression of c-FLIP.

@article{Braun2010ResistanceOC,
  title={Resistance of cutaneous anaplastic large-cell lymphoma cells to apoptosis by death ligands is enhanced by CD30-mediated overexpression of c-FLIP.},
  author={Frank K. Braun and Burkhard Hirsch and Nadya Al-Yacoub and Horst D{\"u}rkop and Chalif Assaf and Marshall E. Kadin and Wolfram Sterry and J{\"u}rgen Eberle},
  journal={The Journal of investigative dermatology},
  year={2010},
  volume={130 3},
  pages={
          826-40
        }
}
Death ligands, including TNF-alpha, CD95L/FasL, and TRAIL, mediate safeguard mechanisms against tumor growth and critically contribute to lymphocyte homeostasis. We investigated death receptor-mediated apoptosis and CD30/CD95 crosstalk in four CD30-positive cell lines of cutaneous anaplastic large-cell lymphoma (cALCL). Whereas CD95 stimulation strongly induced apoptosis in cALCL cells, the pro-apoptotic pathways of TNF-alpha and TRAIL were completely blocked at an early step. Expression of TNF… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Countering TRAIL Resistance in Melanoma

  • Cancers
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Anaplastic large cell lymphoma: twenty-five years of discovery.

  • Archives of pathology & laboratory medicine
  • 2011
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

Pathobiology of CD30+ cutaneous T-cell lymphomas.

  • Journal of cutaneous pathology
  • 2006
VIEW 8 EXCERPTS