Resistance of corneal RFUVA–cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases.

@article{Zhang2013ResistanceOC,
  title={Resistance of corneal RFUVA–cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases.},
  author={Yuntao Zhang and Xiuli Mao and Tyler Schwend and Stacy L Littlechild and Gary Conrad},
  journal={Investigative ophthalmology & visual science},
  year={2013},
  volume={54 2},
  pages={
          1014-25
        }
}
PURPOSE Extracellular matrix metalloproteinases (MMPs) are thought to play a crucial role in corneal degradation associated with the pathological progression of keratoconus. Currently, corneal cross-linking by riboflavin and ultraviolet A (RFUVA) has received significant attention for treatment of keratoconus. However, the extent to which MMPs digest cross-linked collagen and small leucine-rich proteoglycans (SLRPs) remains unknown. In this study, the resistance of RFUVA-cross-linked collagens… CONTINUE READING

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