Resistance of SHP-null mice to bile acid-induced liver damage.


The orphan nuclear hormone receptor SHP (gene designation NROB2) is an important component of a negative regulatory cascade by which high levels of bile acids repress bile acid biosynthesis. Short term studies in SHP null animals confirm this function and also reveal the existence of additional pathways for bile acid negative feedback regulation. We have… (More)


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@article{Wang2003ResistanceOS, title={Resistance of SHP-null mice to bile acid-induced liver damage.}, author={Li Wang and Yunqing Han and C Kim and Yoon-Kwang Lee and David D. Moore}, journal={The Journal of biological chemistry}, year={2003}, volume={278 45}, pages={44475-81} }