Resistance of Haemophilus influenzae to reactive nitrogen donors and gamma interferon-stimulated macrophages requires the formate-dependent nitrite reductase regulator-activated ytfE gene.

@article{Harrington2009ResistanceOH,
  title={Resistance of Haemophilus influenzae to reactive nitrogen donors and gamma interferon-stimulated macrophages requires the formate-dependent nitrite reductase regulator-activated ytfE gene.},
  author={Jane Colleen Harrington and Sandy M. S. Wong and Charles V. Rosadini and Oleg M Garifulin and Victor Boyartchuk and Brian J. Akerley},
  journal={Infection and immunity},
  year={2009},
  volume={77 5},
  pages={1945-58}
}
Haemophilus influenzae efficiently colonizes and persists at the human nasopharyngeal mucosa, causing disease when it spreads to other sites. Nitric oxide (NO) represents a major antimicrobial defense deployed by host cells in locations colonized by H. influenzae during pathogenesis that are likely to vary in oxygen levels. Formate-dependent nitrite reductase regulator (FNR) is an oxygen-sensitive regulator in several bacterial pathogens. We report that fnr of H. influenzae is required for… CONTINUE READING

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