Resistance mechanisms of gastrointestinal cancers: why does conventional chemotherapy fail?

@article{Gieseler2003ResistanceMO,
  title={Resistance mechanisms of gastrointestinal cancers: why does conventional chemotherapy fail?},
  author={Frank Gieseler and Phillip Rudolph and Alison Joan Klein and Ulrich Robert Foelsch},
  journal={International Journal of Colorectal Disease},
  year={2003},
  volume={18},
  pages={470-480}
}
BackgroundGastrointestinal cancers belong to the most important causes of cancer death in the Western world. Because cure can be achieved only by complete surgical removal of the tumor, and most patients have metastasis at the time point of diagnosis, the majority of patients receive chemotherapy.DiscussionIndications for chemotherapy are either the prevention of recurrence after tumor resection (neoadjuvant or adjuvant) or palliative treatment if the tumor is already widespread at diagnosis… CONTINUE READING
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