Resistance mechanisms in human sarcoma mutants derived by single-step exposure to paclitaxel (Taxol).


A fluctuation analysis experiment was performed by exposing 15 expanded populations of MES-SA sarcoma cells to paclitaxel (Taxol) at a concentration of 10 nM for 7 days. The mutation rate was approximately 8 multiplied by 10(-7)/cell generation. ANOVA supports a stochastic cell survival mechanism of spontaneous mutation rather than induction of an adaptive… (More)


  • Presentations referencing similar topics