Resistance emerges to second-generation antiandrogens in prostate cancer.

@article{Nelson2013ResistanceET,
  title={Resistance emerges to second-generation antiandrogens in prostate cancer.},
  author={William Andrew Nelson and Srinivasan Thomas Yegnasubramanian},
  journal={Cancer discovery},
  year={2013},
  volume={3 9},
  pages={971-4}
}
The appearance of a mutant androgen receptor, AR(F876L), in prostate cancer cells chronically exposed to enzalutamide or ARN-509 promotes a switch from antagonist to agonist receptor function, undermining the potential long-term effectiveness of these second-generation antiandrogen drugs. 

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