Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.

@article{Mutero1994ResistanceassociatedPM,
  title={Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.},
  author={Annick Mutero and Madeleine Pralavorio and Jean Marc Bride and Didier Fournier},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 13},
  pages={5922-6}
}
Extensive utilization of pesticides against insects provides us with a good model for studying the adaptation of a eukaryotic genome to a strong selective pressure. One mechanism of resistance is the alteration of acetylcholinesterase (EC 3.1.1.7), the molecular target for organophosphates and carbamates. Here, we report the sequence analysis of the Ace gene in several resistant field strains of Drosophila melanogaster. This analysis resulted in the identification of five point mutations… CONTINUE READING

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