Resistance against the membrane attack complex of complement induced in porcine endothelial cells with a Gal alpha(1-3)Gal binding lectin: up-regulation of CD59 expression.

@article{Dalmasso2000ResistanceAT,
  title={Resistance against the membrane attack complex of complement induced in porcine endothelial cells with a Gal alpha(1-3)Gal binding lectin: up-regulation of CD59 expression.},
  author={Agustin P. Dalmasso and Barbara Benson and J S Johnson and Cheryl A. Lancto and Mitchell S. Abrahamsen},
  journal={Journal of immunology},
  year={2000},
  volume={164 7},
  pages={3764-73}
}
Endothelial cells (EC) play central roles in vascular physiology and pathophysiology. EC activation results in proinflammatory activities with production of cytokines and expression of adhesion molecules. However, we have shown before in a model of xenotransplantation that prolonged stimulation of porcine EC with human anti-porcine IgM natural Abs can activate the cells to become resistant against cytotoxicity by the membrane attack complex of complement (MAC). Now we report the major… CONTINUE READING
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