Resistance, regulatory and production genes for the antibiotic methylenomycin are clustered.

@article{Chater1985ResistanceRA,
  title={Resistance, regulatory and production genes for the antibiotic methylenomycin are clustered.},
  author={Keith F. Chater and Celia J. Bruton},
  journal={The EMBO journal},
  year={1985},
  volume={4 7},
  pages={1893-7}
}
At least 17 kb of DNA from the large unisolatable Streptomyces coelicolor A3(2) plasmid SCP1 are concerned with methylenomycin biosynthesis. Mutational cloning analysis, using insert-directed integration of att site deleted phage vectors into an SCP1-containing host, provided evidence of two large transcription units, of at least 6.6 kb and 9.5 kb. At the leftmost apparent end of the larger (left-hand) transcription unit is a region apparently involved in negative regulation of methylenomycin… CONTINUE READING