Resiniferatoxin and botulinum toxin type A for treatment of lower urinary tract symptoms.

@article{Cruz2007ResiniferatoxinAB,
  title={Resiniferatoxin and botulinum toxin type A for treatment of lower urinary tract symptoms.},
  author={Francisco J. G{\'o}mez-de la Cruz and Paulo Dinis},
  journal={Neurourology and urodynamics},
  year={2007},
  volume={26 6 Suppl},
  pages={920-7}
}
Resiniferatoxin (RTX) and botulinum toxin subtype A (BTX-A) are increasingly viewed as potential treatments for lower urinary tract symptoms (LUTS) refractory to conventional therapy. RTX, a capsaicin analogue devoid of severe pungent properties, acts by desensitizing the transient receptor potential vanilloid type 1 (TRPV1) receptor and inactivating C-fibers. BTX-A cleaves soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins in afferent and efferent nerve… CONTINUE READING