Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids.

@article{Acs1995ResiniferatoxinamideAA,
  title={Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids.},
  author={George Acs and Jeewoo Lee and Victor E. Marquez and Shaomeng Wang and Garth W. Milne and L Du and Nancy E. Lewin and Peter M. Blumberg},
  journal={Journal of neurochemistry},
  year={1995},
  volume={65 1},
  pages={301-18}
}
The naturally occurring diterpene resiniferatoxin (RTX) is an ultrapotent analogue of capsaicin. Acting on polymodal afferent neurons, RTX induces a generally similar pattern of responses as does capsaicin. However, the two compounds, as well as other vanilloid derivatives, display different relative potencies for different responses. In the present study, we examined the vanilloid-like activities of two new derivatives, the amide analogue of RTX and phorbol 12,13-dibenzoate 20… CONTINUE READING