Resiliency and vulnerability in the HER2-HER3 tumorigenic driver.

  title={Resiliency and vulnerability in the HER2-HER3 tumorigenic driver.},
  author={Dhara N. Amin and Natalia V. Sergina and Deepika Ahuja and Martin McMahon and Jimmy A Blair and Donghui Wang and Byron Hann and Kevin Koch and Kevan M. Shokat and Mark M. Moasser},
  journal={Science translational medicine},
  volume={2 16},
About 25% of breast cancers harbor the amplified oncogene human epidermal growth factor receptor 2 (HER2) and are dependent on HER2 kinase function, identifying HER2 as a vulnerable target for therapy. However, HER2-HER3 signaling is buffered so that it is protected against a nearly two-log inhibition of HER2 catalytic activity; this buffering is driven by the negative regulation of HER3 by Akt. We have now further characterized HER2-HER3 signaling activity and have shown that the compensatory… CONTINUE READING
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