Residues of genotoxic alkyl mesylates in mesylate salt drug substances: real or imaginary problems?

  • David J Snodin
  • Published 2006 in Regulatory toxicology and pharmacology : RTP

Abstract

Mesylate esters of short-chain (n = 1-3) alcohols are reactive, direct-acting, genotoxic and possibly carcinogenic alkylating agents. Their chemical and biological properties appear to correlate well with Swain-Scott s constants; for example, high S(N)1 character (low s value) is associated with enhanced carcinogenic potential, but also a rapid hydrolysis… (More)

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Cite this paper

@article{Snodin2006ResiduesOG, title={Residues of genotoxic alkyl mesylates in mesylate salt drug substances: real or imaginary problems?}, author={David J Snodin}, journal={Regulatory toxicology and pharmacology : RTP}, year={2006}, volume={45 1}, pages={79-90} }