Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide.

@article{Thompson1999ResiduesIT,
  title={Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide.},
  author={S. Thompson and S. A. Arden and G. Marshall and P. Wingrove and P. Whiting and K. Wafford},
  journal={Molecular pharmacology},
  year={1999},
  volume={55 6},
  pages={
          993-9
        }
}
GABAA receptors in cerebellar granule cells are unique in expressing a subtype containing the alpha6 subunit. This receptor subtype has high affinity for GABA and produces a degree of tonic inhibition on cerebellar granule cells, modulating the firing of these cells via spillover of GABA from GABAergic synapses. This receptor subtype also has selective affinity for the diuretic furosemide over receptors containing other alpha-subunits. Furosemide exhibits approximately 100-fold selectivity for… Expand
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