Residues in the 11 A channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors.

Abstract

Histone deacetylase 1 (HDAC1) has been linked to cell growth and cell cycle regulation, which makes it a widely recognized target for anticancer drugs. Whereas variations of the metal-binding and capping groups of HDAC inhibitors have been studied extensively, the role of the linker region is less well known, despite the potency of inhibitors with diverse… (More)
DOI: 10.1021/jm800081j

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@article{Weerasinghe2008ResiduesIT, title={Residues in the 11 A channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors.}, author={Sujith V. W. Weerasinghe and Guillermina Estiu and Olaf G. Wiest and Mary Kay H Pflum}, journal={Journal of medicinal chemistry}, year={2008}, volume={51 18}, pages={5542-51} }