Residues important for K+ ion transport in the K+-dependent Na+-Ca2+ exchanger (NCKX2).

@article{Szerencsei2018ResiduesIF,
  title={Residues important for K+ ion transport in the K+-dependent Na+-Ca2+ exchanger (NCKX2).},
  author={R T Szerencsei and Shitian Cai and Robert T. Szerencsei and Paul P M Schnetkamp},
  journal={Cell calcium},
  year={2018},
  volume={74},
  pages={
          61-72
        }
}
K+-dependent Na+-Ca2+ exchangers (NCKXs) play an important role in Ca2+ homeostasis in many tissues. NCKX proteins are bi-directional plasma membrane Ca2+-transporters which utilize the inward Na+ and outward K+ gradients to move Ca2+ ions into and out of the cytosol (4Na+:1Ca2+ + 1 K+). In this study, we carried out scanning mutagenesis of all the residues of the highly conserved α-1 and α-2 repeats of NCKX2 to identify residues important for K+ transport. These structural elements are thought… CONTINUE READING
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