Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion.

@article{Zhu2002ResiduesS,
  title={Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion.},
  author={G Z Zhu and Brent J. Miller and Claude Boucheix and Eric Rubinstein and Christopher C. Liu and Richard O Hynes and Diana Gold Myles and Paul Primakoff},
  journal={Development},
  year={2002},
  volume={129 8},
  pages={1995-2002}
}
Gamete fusion is the fundamental first step initiating development of a new organism. Female mice with a gene knockout for the tetraspanin CD9 (CD9 KO mice) produce mature eggs that cannot fuse with sperm. However, nothing is known about how egg surface CD9 functions in the membrane fusion process. We found that constructs including CD9's large extracellular loop significantly inhibited gamete fusion when incubated with eggs but not when incubated with sperm, suggesting that CD9 acts by… CONTINUE READING
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