Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block.

@article{Feng2001ResidueGO,
  title={Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block.},
  author={Zhong-Ping Feng and Jawed Hamid and Clinton Doering and Gregory M. Bosey and Terrance Preston Snutch and Gerald W Zamponi},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 19},
  pages={
          15728-35
        }
}
We recently reported that amino acid residues contained within a putative EF hand motif in the domain III S5-H5 region of the alpha(1B) subunit affected the relative barium:calcium permeability of N-type calcium channels (Feng, Z. P., Hamid, J., Doering, C., Jarvis, S. E., Bosey, G. M., Bourinet, E., Snutch, T. P., and Zamponi, G. W. (2001) J. Biol. Chem. 276, 5726-5730). Since this region partially overlaps with residues previously implicated in block of the channel by omega-conotoxin GVIA, we… CONTINUE READING

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