Residual viral replication during antiretroviral therapy boosts human immunodeficiency virus type 1-specific CD8+ T-cell responses in subjects treated early after infection.

@article{Ortiz2002ResidualVR,
  title={Residual viral replication during antiretroviral therapy boosts human immunodeficiency virus type 1-specific CD8+ T-cell responses in subjects treated early after infection.},
  author={Gabriel M. Ortiz and Jennifer C C Hu and Joshua A Goldwitz and Rohit Chandwani and Marie Larsson and Nina Bhardwaj and Sebastian Bonhoeffer and Bharat Ramratnam and Linqi Zhang and Martin M Markowitz and Douglas F Nixon},
  journal={Journal of virology},
  year={2002},
  volume={76 1},
  pages={411-5}
}
Human immunodeficiency virus type 1 (HIV-1)-infected subjects treated early after infection have preserved HIV-1-specific CD4+ T-cell function. We studied the effect of highly active antiretroviral therapy (HAART) on the frequency of HIV-1-specific CD8+ T cells in patients treated during early (n = 31) or chronic (n = 23) infection. The degree of viral suppression and time of initiation of treatment influenced the magnitude of the CD8+ T-cell response. HIV-1-specific CD8+ T cells can increase… CONTINUE READING

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