Residual learning deficit after heavy exposure to cannabis or alcohol in rats.

@article{Fehr1976ResidualLD,
  title={Residual learning deficit after heavy exposure to cannabis or alcohol in rats.},
  author={K A Fehr and Harold Kalant and A. Eugene Leblanc},
  journal={Science},
  year={1976},
  volume={192 4245},
  pages={1249-51}
}
Acute oral administration of cannabis extract to rats (tetrahydrocannabinol dose, 10 milligrams per kilogram) impaired maze learning. The impairment was more marked after ten daily doses of the same size. After 1, 2, or 3 months' pretreatment with the same daily dose, followed by a 25-day drug-free period, no residual learning impairment was found. However, 6 months of daily administration of cannabis (tetrahydrocannabinol, 20 milligrams per kilogram) or alcohol (6 grams per kilogram) produced… CONTINUE READING

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