Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations.

@article{Xiao1991ResidualG3,
  title={Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations.},
  author={Hua Xiao and Mikl{\'o}s K{\'a}lm{\'a}n and Kenji Ikehara and Sharon Zemel and G. Glaser and Michael Cashel},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 9},
  pages={5980-90}
}
It was known previously that 1) the relA gene of Escherichia coli encodes an enzyme capable of guanosine 3',5'-bispyrophosphate (ppGpp) synthesis, 2) an uncharacterized source of ppGpp synthesis exists in relA null strains, and 3) cellular degradation of ppGpp is mainly due to a manganese-dependent ppGpp 3'-pyrophosphohydrolase encoded by the spoT gene. Here, the effects of spoT gene insertions and deletions are compared with analogous alterations in neighboring genes in the spo operon and… CONTINUE READING
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