Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: a meta-analysis.

  title={Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: a meta-analysis.},
  author={Amy M. Schreiner and Michael E Dunn},
  journal={Experimental and clinical psychopharmacology},
  volume={20 5},
  • A. SchreinerM. Dunn
  • Published 25 June 2012
  • Psychology, Biology
  • Experimental and clinical psychopharmacology
Cannabis is the most widely used illicit drug in the U.S., and the number of illicit and licit users is rising. Lasting neurocognitive changes or deficits as a result of use are frequently noted despite a lack of clarity in the scientific literature. In an effort to resolve inconsistencies in the evidence of lasting residual effects of cannabis use, we conducted two meta-analyses. First, we updated a previous meta-analysis on broad nonacute cognitive effects of cannabis use through inclusion of… 

Figures and Tables from this paper

Adverse Effects of Cannabis Use on Neurocognitive Functioning: A Systematic Review of Meta- Analytic Studies

Abstract Objective: As the perceived risk of cannabis use continues to decline among youths and access continues to increase, it has become more important to synthesize the rapidly growing literature

Weighing the Evidence: A Systematic Review on Long-Term Neurocognitive Effects of Cannabis Use in Abstinent Adolescents and Adults

Findings are mixed regarding impairments in inhibition, impulsivity and decision making for CU, but there is a trend towards worse performance, and heavy use is found to be more consistently associated with effects in diverse domains than early age of onset.

Evidence on the acute and residual neurocognitive effects of cannabis use in adolescents and adults: a systematic meta-review of meta-analyses.

Meta-analytical data on the acute effects of cannabis use on neurocognitive function have shown that cannabis intoxication leads to small to moderate deficits in several cognitive domains, suggesting that the detrimental effects of Cannabis persist beyond acute intake.

Cannabis use and neurocognitive functioning in a non-clinical sample of users.

Effects of regular cannabis use on neurocognition, brain structure, and function: a systematic review of findings in adults

It is suggested that regular cannabis use is associated with mild cognitive changes in addition to structural and functional alterations in the brain in adults, and the morphological alterations could ultimately affect brain organization and function.

The acute effects of cannabis on human executive function

It is suggested that cannabis use results in acute impairment of inhibition, with the strongest effects after pulmonary administration of higher doses of [INCREMENT]9-tetrahydrocannabinol.

Cannabis and Cognitive Functioning: From Acute to Residual Effects, From Randomized Controlled Trials to Prospective Designs

The association between cannabis and cognition is likely explained by common antecedents, such that genetic and shared environment factors predispose individuals to both cannabis use and cognitive deficits, and to a lesser degree, neurotoxic effects.

Heavy cannabis use, dependence and the brain: a clinical perspective

Current evidence of long‐term effects of daily cannabis use and cannabis use disorder on brain‐related outcomes is suggestive rather than conclusive, but use is associated with psychiatric morbidity and with cognitive impairments that recover after a period of abstinence.



Non-acute (residual) neurocognitive effects of cannabis use: A meta-analytic study

The results indicate that there might be decrements in the ability to learn and remember new information in chronic users, whereas other cognitive abilities are unaffected, and the small magnitude of these effect sizes suggests that if cannabis compounds are found to have therapeutic value, they may have an acceptable margin of safety under the more limited conditions of exposure that would likely obtain in a medical setting.

The residual neuropsychological effects of cannabis: the current status of research.

Neuropsychological consequences of regular marijuana use: a twin study

The results indicate an absence of marked long-term residual effects of marijuana use on cognitive abilities.

Cognitive Measures in Long‐Term Cannabis Users

It is suggested that cannabis‐associated cognitive deficits are reversible and related to recent cannabis exposure rather than irreversible and related with increasing duration of lifetime cannabis use.

Cognitive functioning of long-term heavy cannabis users seeking treatment.

It is confirmed that long-term heavy cannabis users show impairments in memory and attention that endure beyond the period of intoxication and worsen with increasing years of regular cannabis use.

An Evidence-Based Review of Acute and Long-Term Effects of Cannabis Use on Executive Cognitive Functions

The research on the acute, residual, and long-term effects of cannabis use on executive functions is reviewed and the implications for treatment are discussed.

Cannabis: Psychological effects of chronic heavy use

It was suggested that heavy users of this drug did not show test performances indicating impairment of psychological functioning comparable to other types of organic cerebral dysfunction, nor did they show chronic changes on dimensions responsive to immediate intoxication.

Neuropsychological performance in long-term cannabis users.

Some cognitive deficits appear detectable at least 7 days after heavy cannabis use but appear reversible and related to recent cannabis exposure rather than irreversible andrelated to cumulative lifetime use.

Acute and Non-acute Effects of Cannabis on Brain Functioning and Neuropsychological Performance

  • R. Gonzalez
  • Psychology, Biology
    Neuropsychology Review
  • 2007
The scientific literature on cannabis use, neuropsychological deficits and differences in brain functioning, and the dire impact of drug addiction on a person’s life and everyday functioning are reviewed, providing evidence for converging findings, and highlighting areas in need of further investigation.