Residual effect of chlorhexidine gluconate in 4-day plaque regrowth crossover trials, and its implications for study design.


The efficacy of oral hygiene agents in preventing the accumulation of plaque from a zero baseline is conveniently evaluated in the 4-day plaque regrowth model. In many studies a panel of volunteers has been used to compare several agents according to a highly efficient Latin square based crossover design. Often chlorhexidine gluconate is included as a… (More)


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