Residual dipolar couplings: synergy between NMR and structural genomics.

@article{AlHashimi2002ResidualDC,
  title={Residual dipolar couplings: synergy between NMR and structural genomics.},
  author={Hashim M Al-Hashimi and Dinshaw J. Patel},
  journal={Journal of biomolecular NMR},
  year={2002},
  volume={22 1},
  pages={1-8}
}
Structural genomics is on a quest for the structure and function of a significant fraction of gene products. Current efforts are focusing on structure determination of single-domain proteins, which can readily be targeted by X-ray crystallography, NMR spectroscopy and computational homology modeling. However, comprehensive association of gene products with functions also requires systematic determination of more complex protein structures and other biomolecules participating in cellular… CONTINUE READING

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View 10 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Protein Sci

A C Drohat, N Tjandra, D M Baldisseri, D J Weber
Protein Sci • 1999
View 8 Excerpts
Highly Influenced

Proc. Natl. Acad. Sci. USA

K Pervushin, R Riek, G Wider, K Wuthrich
Proc. Natl. Acad. Sci. USA • 1997
View 4 Excerpts
Highly Influenced

Curr. Opin. Chem. Biol

J H Prestegard, A I Kishore
Curr. Opin. Chem. Biol • 2001
View 4 Excerpts
Highly Influenced

J. Mol Biol

H M Al-Hashimi, Y Gosser, +3 authors D J Patel
J. Mol Biol • 2002
View 1 Excerpt

Accounts Chem. Res

A Majumdar, D J Patel
Accounts Chem. Res • 2001
View 1 Excerpt

Biochemistry

J H Prestegard, H Valafar, J Glushka, F Tian
Biochemistry • 2001

Curr. Opin. Drug. Discov. Devel

M Norin, M Sundstrom
Curr. Opin. Drug. Discov. Devel • 2001
View 1 Excerpt

Curr. Opin. Struct. Biol

L Zidek, R Stefl, V Sklenar
Curr. Opin. Struct. Biol • 2001

J Am Chem Soc

M Zweckstetter, A Bax
J Am Chem Soc • 2001
View 1 Excerpt

Meth. Enzymol

A G Palmer, rd, C D Kroenke, J P Loria
Meth. Enzymol • 2001

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