Residual adrenal function in autoimmune Addison's disease: improvement after tetracosactide (ACTH1-24) treatment.

@article{Gan2014ResidualAF,
  title={Residual adrenal function in autoimmune Addison's disease: improvement after tetracosactide (ACTH1-24) treatment.},
  author={Earn Hui Gan and Katie D. R. Macarthur and Anna L Mitchell and Beverly A. Hughes and P Perros and Stephen G. Ball and Robert Andrew James and Richard Quinton and Shu Chen and Jadwiga Furmaniak and Wiebke Arlt and Simon H. S. Pearce},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2014},
  volume={99 1},
  pages={
          111-8
        }
}
CONTEXT Despite lifelong steroid hormone replacement, there is excess morbidity and mortality associated with autoimmune Addison's disease. In health, adrenocortical cells undergo continuous self-renewal from a population of subcapsular progenitor cells, under the influence of ACTH, suggesting a therapeutic possibility. OBJECTIVE We aimed to determine whether tetracosactide (synthetic ACTH1-24) could revive adrenal steroidogenic function in autoimmune Addison's disease. DESIGN, SETTING, AND… CONTINUE READING
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