Residual Solvent Testing: A Review of Gas-Chromatographic and Alternative Techniques

@article{Bhymer2003ResidualST,
  title={Residual Solvent Testing: A Review of Gas-Chromatographic and Alternative Techniques},
  author={Clayton B'hymer},
  journal={Pharmaceutical Research},
  year={2003},
  volume={20},
  pages={337-344}
}
The purpose of this brief review is to describe and discuss some of the current analytic procedures including gas-chromatographic and alternative techniques for residual solvent testing. Residual solvents, or organic volatile impurities, are a potential toxic risk for pharmaceutic products and have been a concern of manufacturers for many years. Residual solvents have had official limits in the United States as set in USP XXV and by the FDA in 1997 and have been monitored by most pharmaceutical… CONTINUE READING
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