Residual NADPH oxidase and survival in chronic granulomatous disease.

@article{Kuhns2010ResidualNO,
  title={Residual NADPH oxidase and survival in chronic granulomatous disease.},
  author={Douglas B Kuhns and W. Gregory Alvord and Theo Heller and Jordan J Feld and Kristen M. Pike and Beatriz E. Marciano and Gulbu Uzel and Suk See DeRavin and Debra A. Long Priel and Benjamin R Soule and Kol A. Zarember and Harry L Malech and Steven M Holland and John I Gallin},
  journal={The New England journal of medicine},
  year={2010},
  volume={363 27},
  pages={
          2600-10
        }
}
BACKGROUND Failure to generate phagocyte-derived superoxide and related reactive oxygen intermediates (ROIs) is the major defect in chronic granulomatous disease, causing recurrent infections and granulomatous complications. Chronic granulomatous disease is caused by missense, nonsense, frameshift, splice, or deletion mutations in the genes for p22(phox), p40(phox), p47(phox), p67(phox) (autosomal chronic granulomatous disease), or gp91(phox) (X-linked chronic granulomatous disease), which… CONTINUE READING

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