Residual Effects of Hypnotics

@article{Vermeeren2004ResidualEO,
  title={Residual Effects of Hypnotics},
  author={Annemiek Vermeeren},
  journal={CNS Drugs},
  year={2004},
  volume={18},
  pages={297-328}
}
The risk of ‘hangover’ effects, e.g. residual daytime sleepiness and impairment of psychomotor and cognitive functioning the day after bedtime administration, is one of the main problems associated with the use of hypnotics. However, the severity and duration of these effects varies considerably between hypnotics and is strongly dependent on the dose administered.This article reviews epidemiological evidence on the effect of hypnotics on patients’ risk for accidents such as traffic accidents… 
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TLDR
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References

SHOWING 1-10 OF 119 REFERENCES
Hypnotics and behavior.
The use of sedative/hypnotic medication and its correlation with falling down in the hospital.
The relationship between reports of falling down and the administration of sedative/hypnotics or other psychotropic drugs was examined during a 1-year period in a 1,000-bed teaching hospital. It was
Hypnotic action and residual effects of a single bedtime dose of temazepam.
TLDR
The results indicate that temazepam 20 mg in young adults has a reliable hypnotic effect without significant residual sequelae and no evidence for rebound insomnia in the 3 nights following drug intake.
Zopiclone. An update of its pharmacology, clinical efficacy and tolerability in the treatment of insomnia.
TLDR
Although the available data on rebound insomnia and dependence liability are encouraging, potential differences between zopiclone and the benzodiazepines in these respects may have little clinical relevance in the context of short term intermittent use of hypnotics, as it currently recommended.
A comparison of temazepam and flurazepam in terms of sleep quality and residual changes in activation and performance.
TLDR
Large significant, residual effects of flurazepam were seen on activation and performance (correct detections and reaction times) while temazepams had little effect on activationand produced only a small significant residual impairment of reaction times.
Pharmacodynamic profile of Zaleplon, a new non‐benzodiazepine hypnotic agent
TLDR
It is shown that zaleplon 10 mg has little or no residual effect when administered in the middle of the night, as late as 1 h before waking, and is devoid of impairment of driving abilities as assessed by actual driving 4’h after dose administration.
Residual effect of single and repeated doses of midazolam and nitrazepam in relation to their plasma concentrations
TLDR
Hypnotic effect, judged by the classical sleep variables, showed that the drugs were more or less equal and were superior to placebo, and impairment induced by both drugs was revealed, but, in the midazolam group the effect subsided during the trial period.
Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers
TLDR
Zopiclone and temazepam can be considered as effective hypnotics in elderly subjects when administered in that dosage and the superiority of zopiclones on sleep architecture may be related to a more specific action of zopylone at the GABA-A benzodiazepine receptor complex.
Management of insomnia.
  • C. Kirkwood
  • Psychology, Medicine
    Journal of the American Pharmaceutical Association
  • 1999
Residual effects of hypnotics
TLDR
Both drugs were effective hypnotics according to the ratings but butobarbitone had more subjective “hangover” the following morning but the evoked response was affected most by 10 mg nitrazepam.
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