Residual Effects of Hypnotics

@article{Vermeeren2004ResidualEO,
  title={Residual Effects of Hypnotics},
  author={Annemiek Vermeeren},
  journal={CNS Drugs},
  year={2004},
  volume={18},
  pages={297-328}
}
The risk of ‘hangover’ effects, e.g. residual daytime sleepiness and impairment of psychomotor and cognitive functioning the day after bedtime administration, is one of the main problems associated with the use of hypnotics. However, the severity and duration of these effects varies considerably between hypnotics and is strongly dependent on the dose administered.This article reviews epidemiological evidence on the effect of hypnotics on patients’ risk for accidents such as traffic accidents… Expand
Effects of Hypnotics on Sleep and Quality of Life in Insomnia
TLDR
Limited evidence is provided that newer formulations and different treatment schedules, including intermittent use, can sustain hypnotic efficacy with the Z drugs over longer periods, enhancing QOL and waking function, and without rebound insomnia following withdrawal. Expand
7 of Hypnotics on Sleep and Quality of Life in Insomnia
Summary This chapter provides an overview of the effects of hypnotics on sleep and quality of life (QOL). In the 1970s it was accepted that a consequence of taking longer acting benzodiazepineExpand
Temazepam 20 mg improves sleep without residual effects in elderly drivers.
TLDR
The aim of this study was to determine the residual effects of temazepam 20 mg and zopiclone 7.5 mg on actual driving performance in healthy elderly subjects, using the same tests and procedures as in a previous study with young volunteers. Expand
Effects of the use of hypnotics on cognition.
TLDR
No hypnotic has been found yet to improve daytime performance, and studies on long-term use of benzodiazepine hypnotics suggest that effects on daytime performance may diminish over time due to tolerance, however, there are also studies showing that performance may improve after discontinuation of chronic benzdiazepine use, which suggests that tolerance may not be complete. Expand
The benzodiazepine hangover: next-day residual effects on driving performance
Benzodiazepines (BZDs) are implicated in a considerable proportion of road crashes in Australia (behind only alcohol and cannabis respectively). A review of reported patterns of BZD use,Expand
Residual effects of zolpidem, zopiclone and flunitrazepam on the processing of visual information in driving context
Abstract Drivers who had taken hypnotic medications such as benzodiazepines are over-represented in road accidents. Experimental studies show that, even the day after, these drugs induce anExpand
Residual effects of flunitrazepam, zopiclone and zolpidem in elderly drivers submitted to simulated driving accidents
TLDR
Zopiclone and zolpidem have thus rapidly become very frequently prescribed hypnotics and are among the five most frequently used in Europe and become a challenge in the context of road safety. Expand
Residual Effects of Short Half-life Nonbenzodiazepine Hypnotics
Background Since their introduction at the beginning of the 1990s the short half-life nonbenzodiazepine hypnotics, zolpidem and zopiclone, rapidly were among the most frequently prescribed hypnotics.Expand
The effects of acute treatment with ramelteon, triazolam, and placebo on driving performance, cognitive function, and equilibrium function in healthy volunteers
TLDR
Ramelteon may affect road-tracking performance, visual attention and/or psychomotor speed measured by Trail-Making Test part A, and body balance in acute dosing, and Physicians should consider risks and benefits when prescribing both drugs. Expand
The residual effects of N-desmethyldiazepam in patients
TLDR
After the week of treatment, the benzodiazepine groups were achieving the best quality of self-rated sleep with fewest subjective feelings of hang-over, however, the higher dose of N-desmethyldiazepam was associated with less improvement, i.e., some impairment relative to placebo was detected. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 119 REFERENCES
Hypnotics and behavior.
TLDR
The observation that benzodiazepines produce amnesia emerged from reports of their clinical use as presurgery medications, with the magnitude of the effect being a function of route of administration, dose, and the pharmacokinetics of the particular drug. Expand
The use of sedative/hypnotic medication and its correlation with falling down in the hospital.
The relationship between reports of falling down and the administration of sedative/hypnotics or other psychotropic drugs was examined during a 1-year period in a 1,000-bed teaching hospital. It wasExpand
Hypnotic action and residual effects of a single bedtime dose of temazepam.
TLDR
The results indicate that temazepam 20 mg in young adults has a reliable hypnotic effect without significant residual sequelae and no evidence for rebound insomnia in the 3 nights following drug intake. Expand
Triazolam and zolpidem: a comparison of their psychomotor, cognitive, and subjective effects in healthy volunteers
TLDR
The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam and the imidazopyridine hypnotic zolpidem were compared in 11 volunteers, in a double-blind, placebo-controlled, crossover design. Expand
Determinants of residual effects of hypnotics.
TLDR
The issues critical to evaluating studies of the effects of hypnotics on performance are discussed, including dose and half-life are important variables in determining the degree to which these daytime effects occur following nighttime use. Expand
Zopiclone. An update of its pharmacology, clinical efficacy and tolerability in the treatment of insomnia.
TLDR
Although the available data on rebound insomnia and dependence liability are encouraging, potential differences between zopiclone and the benzodiazepines in these respects may have little clinical relevance in the context of short term intermittent use of hypnotics, as it currently recommended. Expand
A comparison of temazepam and flurazepam in terms of sleep quality and residual changes in activation and performance.
TLDR
Large significant, residual effects of flurazepam were seen on activation and performance (correct detections and reaction times) while temazepams had little effect on activationand produced only a small significant residual impairment of reaction times. Expand
Pharmacodynamic profile of Zaleplon, a new non‐benzodiazepine hypnotic agent
TLDR
It is shown that zaleplon 10 mg has little or no residual effect when administered in the middle of the night, as late as 1 h before waking, and is devoid of impairment of driving abilities as assessed by actual driving 4’h after dose administration. Expand
Residual effect of single and repeated doses of midazolam and nitrazepam in relation to their plasma concentrations
TLDR
Hypnotic effect, judged by the classical sleep variables, showed that the drugs were more or less equal and were superior to placebo, and impairment induced by both drugs was revealed, but, in the midazolam group the effect subsided during the trial period. Expand
Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers
TLDR
Zopiclone and temazepam can be considered as effective hypnotics in elderly subjects when administered in that dosage and the superiority of zopiclones on sleep architecture may be related to a more specific action of zopylone at the GABA-A benzodiazepine receptor complex. Expand
...
1
2
3
4
5
...